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Most softies in this group release toxins into the water when injured or stressed, so it would be best to remove the colony from the main tank before trying to frag any of it. Someone suggested to me to do a waterchange and then use the old water as a holding tank to do your fragging in.
As some of these toxins are serious enough to affect humans, be sure to protect yourself as well. Wear gloves (elbow length if you can get them) and/or be sure you have no open cuts/scabs or whatever on any surface you'll be putting into the water. I recently had a mild reaction to some true zoanthids that were a little stressed from being shipped, and that really got my attention.
These organisms are less hardy that mushrooms and leathers, so when cutting them, try to get down as close to the rock as possible, even scraping it off if you can. Use the gel type of superglue instead of liquid and you're good to go.
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