I too have built some very large ply/glas tanks with good results.
I highly recommend that all pieces first be coated with a two part food safe epoxy paint on all sides and edges. Essentially you seal the piece so that it effectively is a piece of glass. Then drill as mentioned for screws. Assemble with aquarium silicone as usual and install screws. Finally just run a bead of silicone on the inside seams and smooth with finger unless enough was applied to assemble. Same as glass.
However I am assuming that you really want a super clear front pane which will be impossible.
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