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I have a 150g and used 1/2 ml very small dose. It nuked the little bastard and there is no sight of him. I am doing water change today and just tested the PH it still is sitting at 8.3 I got very little solids from this. I have my plumbing in the basement and do my water changes from down below. I will however use a hose and siphon a bit from the location and see if I pull any solids from that area. It seems to work great though.
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You plumb it, you take it apart, you plumb it, and take it apart, till you plumb it again.
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