The acrylic is much stronger, and the seems won't split like they will on a glass tank. They can handle to accidental bumps to the panels, and strain(torque, like from an earthquake) much better. The obvious, and previously stated downside is the scratchability.
I bought an acrylic 250 because I knew of the possibility of moving (acrylic is much lighter) and it's strength advantage(2 young kids). But, I hate scraping coralline off of acrylic.
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