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I use Holdfast Epoxy made by Marineland. I have used literally dozens (yes dozens) in my tank over the past 5 years. On occassion I have used 4 tubes at once in my 150 gallon reef tank with no obvious problems. The reason that I use so much epoxy is that I have a tall symmetric hexagonal tank with a center overflow. I have LR stacked steeply up against the center overflow, and without use of epoxy, the whole thing would come tumbling down. All I can tell you about is my experience, and with the epoxy mentioned, I have noticed NO ill effects.
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