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The only situation in which I would not plumb the Infinity tank to the main tank is if I were to use it as a quarantine tank, something I doubt I would contemplate due to its size and dimensions. If you think about plumbing it to the main tank, start that planning now, imo. Given its size, I would think that you would enjoy the added stability joining it to the "main" tank would offer, in addition to limiting your maintenance to only one system.
10" on center is fine. Some will go farther apart, up to 12", and others would go to 8". On horizontal surfaces, I prefer the closer spread and on vertical I cheat and go a bit farther apart.
ps... I would not change what I have done; that is going to leave holes which are worse.
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•Any intelligent fool can make things bigger, more complex, and more violent. It takes a touch of genius - and a lot of courage - to move in the opposite direction.
•Imagination is more important than knowledge.
--Albert Einstein
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