What software are you using to downsize? Even the best options out there (Photoshop) have to make compromises when interpolating the image into the smaller size. Another limiting factor is going to be the fact that you're looking at your image on a monitor, which is only 72dpi, a resolution that would be completely unacceptable in print.
To combat this as much as possible, I always re-sharpen the images after a resize. Ultimately, there's simply no way to completely avoid the loss in clarity at some level.
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