I have been using the Cherrystone clam in my reef for approx a year for filtration and they are doing great!!
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No one has really proven that they do any good at all. So how many is a complete guess.
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My tank was proof enough for me - my nitrates were always 60ppm and above I feed my critters well so I know where the nitrate was coming from. I have changed nothing except added the cherrystones to my fuge 4 at first until the nitrates were down at which time I gave 2 away and the 2 that remain have kept the nitrates 0-5ppm for almost a year.