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Generally, I would not recommend it. Whether you can get away with it or not really depends on the animals you keep and how you aquascape your tank.
Still, 2x250w MH is overkill on a 44g, IMO. 2x150 or 175 will be plenty and the supplemental T5's or PCs unnecessary unless you are trying to create a particular spectrum profile or want them for a dawn/dusk effect. (Personally, I like that.)
You will get more bang for your lighting buck with the lower wattage bulbs and some high quality reflectors instead of a pre-made fixture, and then you can space the lights more appropriately for your tank. The reflectors will be pricey, but they don't take electricity and don't need to be replaced every year.
44g that's 48" long? Weird. How deep is that tank?
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Don't count your gobies before they've metamorphasized.
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